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BCX-1470 methanesulfonate
CAS No. 217099-44-0
BCX-1470 methanesulfonate ( BCX-1470 )
产品货号. M13471 CAS No. 217099-44-0
一种丝氨酸蛋白酶抑制剂，可抑制因子 D (IC50=96 nM) 和 C1s (IC50=1.6 nM) 的酯解活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2827 | 有现货 |
|
| 50MG | ￥11421 | 有现货 |
|
| 100MG | ￥17334 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BCX-1470 methanesulfonate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种丝氨酸蛋白酶抑制剂，可抑制因子 D (IC50=96 nM) 和 C1s (IC50=1.6 nM) 的酯解活性。
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产品描述A serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM); displays 3.4-fold and 200-fold bette than that of trypsin, respectively; inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively); blocks the reverse passive Arthus (RPA) reaction in rats. Thrombosis Phase 1 Discontinued.
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体外实验BCX 1470 methanesulfonate is serine protease inhibitor. BCX 1470 methanesulfonate blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
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体内实验——
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同义词BCX-1470
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通路Immunology/Inflammation
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靶点Complement System
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受体Complement System
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研究领域Cardiovascular Disease
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适应症Thrombosis
化学信息
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CAS Number217099-44-0
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分子量398.4771
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分子式C15H14N2O5S3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCS(=O)(=O)O.C1=CSC(=C1)C(=O)OC2=CC3=C(C=C2)C=C(S3)C(=N)N
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化学全称2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester, methanesulfonate (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Szalai AJ, et al. J Immunol. 2000 Jan 1;164(1):463-8.
2. Babu, Y. S, et al. Patent No. WO 98/55471.
